iPHACE
integrative navigation in pharmacological space
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Interaction Map

Displays the interaction matrix between drugs (in rows) and targets (in columns). The strength of the interaction is reflected by a coloring scheme provided at the bottom-right of the interaction map. Drug-target interactions for which no activity information is available are marked in green (go to Contents for a data completeness analysis). In contrast, dark red cells denote high-affinity drug-target interactions.


White vertical lines separate map regions for different targets, target groups, or target families. Displacing the mouse over a certain region shows the name of the target, group, or family represented in that region of the map. Clicking on a region reloads the map to zoom into that interaction region.

The use of hierarchical classifications for both drugs and targets gives the flexibility to display the interaction map at different hierarchical levels. The user can define the hierarchy level by selecting from a drop-down menu (left for drugs, right for targets) the grouping level at which the interaction map will be displayed.

group by    

There is also the possibility to display only drug-target interactions above/under a certain affinity threshold and to define the type of activity to be displayed.

threshold          

Additional thresholds can be included by clicking on the add button or eliminated by clicking on the remove button. A text with the specified thresholds appears always on the top-right side of the interaction map.

When the row dimension of the interaction map is below 50, rows will be labelled with the drug name, at the Molecule level, or with structure images, at the Scaffold and Framework level. The number of interactions, drugs, and targets displayed in the interaction map appears always at the bottom of the map image.

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